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FAP/AFAP

Intermediate Prognosis
0.50% Prevalence Level 1 Special Populations
Actionable Target
FDA-approved targeted therapies or strong clinical trial evidence available
Genes Involved
APC
Treatment Implications

Hereditary polyposis. May need colectomy.

Recommended Treatments
Surgery
Celecoxib
Family screening
Treatments to Avoid

No specific contraindications noted

Study References

NCCN Genetic

Key Statistics
0.50%
Prevalence in CRC
Yes
Targetable
Clinical Notes
Extracolonic manifestations (desmoids, thyroid).
Information

Category: Special Populations

Evidence Level: Level 1

Last Updated: Dec 7, 2025

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Medical Disclaimer: This information is for educational purposes only and should not replace professional medical advice. Always consult with your oncologist for personalized treatment decisions based on your specific situation.